Cushing Disease

Overproduction of a pituitary gland hormone leads to an overactive adrenal gland. A similar condition called Cushing's syndrome may occur in people, particularly children, who take high doses of corticosteroid medications. It is a cause of Cushing's syndrome characterized by increased secretion of adrenocorticotropic hormone (ACTH) from the anterior pituitary. This is most often as a result of a pituitary adenoma or due to excess production of hypothalamus CRH that stimulates the synthesis of cortisol by the adrenal glands. Pituitary adenomas are responsible for 80% of endogenous Cushing's syndrome, when excluding Cushing's syndrome from exogenously administered corticosteroids.

  • Hyperplasia
  • Dexamethasone suppression test
  • Brain MRI and lipid and cholesterol testing
  • Inferior petrosal sinus sampling
  • Pseudo-cushing states
  • Pheochromocytoma/paraganglioma
  • Symptoms, diagnosis & treatment
  • Hypoaldosteronism and hyperaldosteronism

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Cushing Disease Conference Speakers

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