Endocrine Disorders and Therapies

Gigantism and Other Growth Hormone

Overproduction of growth hormone causes excessive growth. In children, the condition is called gigantism. In adults, it is called acromegaly. Growth hormone stimulates the growth of bones, muscles, and many internal organs. Excessive growth hormone, therefore, leads to abnormally robust growth of all of these tissues. Overproduction of growth hormone is almost always caused by a noncancerous (benign) pituitary tumor (adenoma). Certain rare tumors of the pancreas and lungs also can produce hormones that stimulate the pituitary to produce excessive amounts of growth hormone, with similar consequences.